周兆才

发布时间：2023-12-25浏览次数：7599

教师基本信息：

周兆才教授

办公室：发育生物楼334室

研究方向：

聚焦消化道肿瘤。长期以消化道为主要研究体系，关注肿瘤发生演化以及胃脑轴等跨器官通讯，综合利用单细胞及空间组学、动物模型、代谢及表观遗传、临床样本、类器官、生物信息学等技术体系，着重阐释免疫、神经、上皮等不同类型细胞之间协作与竞争调控胃肠组织稳态维持及失衡导致肿瘤等疾病的功能和机制，特别是从分子细胞信号机制的角度探索中枢及外周神经与胃癌发生发展的关系。

个人简介：

国家杰青、国家重点研发计划首席科学家

国家二级教授、做爱电影特聘教授、做爱电影附属中山医院双聘教授、做爱电影曹娥江转化医学创新中心副院长、做爱电影学位委员会委员及生物学分委会主席、做爱电影学术委员会委员、复杂性状的遗传调控全国重点实验室研究组长。

2004年博士毕业于中国科学技术大学，随后赴美国费城UPenn药做爱电影从事博士后研究（师从抗癌药物Herceptin研发先驱Mark I. Greene教授）。2009年中国科做爱电影百人计划引进回国，历任生物化学与细胞生物学研究所、分子生物学国家重点实验室、细胞生物学国家重点实验室、分子细胞科学卓越创新中心特聘研究员（中科院战略性科技先导专项资助）。2014年百人计划终期评估优秀，同年被授予中科院杰出青年科技创新人才称号，任中科院与高校联合交叉创新团队负责人。2017年获国家自然科学基金委医学部杰青资助。2020年加入做爱电影。担任Nat Cell Biol、Nat Chem Biol、J Clin Invest、J Exp Med、Nat Commun、Cell Res、Cell Rep、Gut等学术期刊审稿人。担任《细胞生物学》、《生命的化学》等期刊编委、中国抗癌协会肿瘤胃肠病学等多个专业委员会委员。

代表性工作揭示了Hippo信号通路调控消化道肿瘤发生及免疫应答的机制与功能，发现了一批疾病诊断标志物和先导药物，推动我国胃癌基础研究走向国际前沿，迄今以通讯作者（含共同）在Nature Immunology (x2)、Cancer Cell (x2)、Journal Clinical Investigation (x2)、Journal Experimental Medicine (x2)、Nature Communications (x3)、EMBO Journal (x3)、Cell Research (x2)、Protein Cell (x2)、Cell Reports、Journal Hepatology 、Cancer Research、Cell Discovery等国际学术期刊发表论文百余篇，被Cell、Nature、F1000Prime等评价和推荐，并获一系列发明专利授权。

授课情况

《癌生物学》、《现代生物学基础与前沿Ⅱ-遗传和发育生物学》

招生专业

遗传学、细胞生物学、生化与分子生物学

科研项目

主持在研或已结题的项目包括：国家自然科学基金委杰出青年项目、原创探索项目、重点项目、香港区域联合项目、面上项目等；国家科技部高技术中心发育代谢重点研发计划（组织器官生长与尺寸控制的信号基础与感知调控专项）；上海市重点项目；多个转化医学研究横向项目。

代表性论文(1-102)

1. Zhu ZH, Ding R, Yu W, Liu Y, Zhou ZC, Liu CY: YAP/TEAD4/SP1-induced VISTA expression as a tumor cell-intrinsic mechanism of immunosuppression in colorectal cancer. Cell Death Differ 2025, 32(5):911-925.

2. Zhang WH, Wang SL, Zhang H, Meng Y, Jiao S, An LW, Zhou ZC: Modeling human gastric cancers in immunocompetent mice. Cancer Biology & Medicine 2024, 21(7):553-570.

3. Wen FP, Han Y, Zhang H, Zhao ZT, Wang WJ, Chen F, Qin WM, Ju JY, An LW, Meng Y et al: Epstein-Barr virus infection upregulates extracellular OLFM4 to activate YAP signaling during gastric cancer progression. Nature Communications 2024, 15(1).

4. Tang Y, Chen F, Fang GM, Zhang H, Zhang YN, Zhu HY, Zhang XR, Han Y, Cao ZF, Guo FH et al: A cofactor-induced repressive type of transcription factor condensation can be induced by synthetic peptides to suppress tumorigenesis. Embo Journal 2024, 43(22):5586-5612.

5. Nie P, Cao Z, Yu R, Dong C, Zhang W, Meng Y, Zhang H, Pan Y, Tong Z, Jiang X et al: Targeting p97–Npl4 interaction inhibits tumor Treg cell development to enhance tumor immunity. Nature immunology 2024, 25(9):1623-1636.

6. Ju JY, Zhang H, Lin MB, Yan ZF, An LW, Cao ZF, Geng DD, Yue JW, Tang Y, Tian LY et al: The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer. Journal of Clinical Investigation 2024, 134(10).

7. Cao ZF, Hou Y, Zhao ZT, Zhang H, Tian LY, Zhang YM, Dong C, Guo FH, Tan LJ, Han Y et al: Reactivating Hippo by drug compounds to suppress gastric cancer and enhance chemotherapy sensitivity. Journal of Biological Chemistry 2024, 300(6).

8. Zhang JL, Chen BN, Li H, Wang YF, Liu XL, Wong KY, Chan WN, Chan AKY, Cheung AHK, Leung KT et al: Cancer-associated fibroblasts potentiate colorectal cancer progression by crosstalk of the IGF2-IGF1R and Hippo-YAP1 signaling pathways. Journal of Pathology 2023, 259(2):205-219.

9. Nie PP, Zhang WH, Meng Y, Lin MB, Guo FH, Zhang H, Tong ZZ, Wang M, Chen F, An LW et al: A YAP/TAZ-CD54 axis is required for CXCR2 CD44 tumor-specific neutrophils to suppress gastric cancer. Protein & cell 2023, 14(7):515-533.

10. Meng Y, Zhao QD, Sang Y, Liao JP, Ye F, Qu SP, Nie PP, An LW, Zhang WH, Jiao S et al: GPNMB Gal-3 hepatic parenchymal cells promote immunosuppression and hepatocellular carcinogenesis. Embo Journal 2023, 42(24):e114060.

11. Meng Y, Ye F, Nie PP, Zhao QD, An LW, Wang WJ, Qu SP, Shen ZM, Cao ZF, Zhang XB et al: Immunosuppressive CD10+ALPL+ neutrophils promote resistance to anti-PD-1 therapy in HCC by mediating irreversible exhaustion of T cells. Journal of Hepatology 2023, 79(6):1435-1449.

12. Li YH, Peng JY, Xia YX, Pan CY, Li Y, Gu WJ, Wang J, Wang CX, Wang Y, Song JW et al: Sufu limits sepsis-induced lung inflammation via regulating phase separation of TRAF6. Theranostics 2023, 13(11):3761-3780.

13. Jiao S, Li CC, Guo FH, Zhang JJ, Zhang H, Cao ZF, Wang WJ, Bu WB, Lin MB, Lü JH et al: SUN1/2 controls macrophage polarization via modulating nuclear size and stiffness. Nature Communications 2023, 14(1):6416.

14. Cao ZF, An LW, Han Y, Jiao S, Zhou ZC: The Hippo signaling pathway in gastric cancer. Acta biochimica et biophysica Sinica 2023, 55(6):893-903.

15. Cao JJ, Ji LL, Zhan YX, Shao X, Xu PC, Wu BT, Chen P, Cheng LY, Zhuang XB, Ou Y et al: MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages. Cellular & molecular immunology 2023, 20(12):1413-1427.

16. Wei W, Tang XF, Jiang N, Ni C, He H, Sun SF, Yu M, Yu CY, Qiu MD, Yan D et al: Chromatin remodeler Znhit1 controls bone morphogenetic protein signaling in embryonic lung tissue branching. Journal of Biological Chemistry 2022, 298(10):102490.

17. Wang YF, Chen HR, Liu WX, Yan H, Zhang YH, Cheung AHK, Zhang JL, Chen BA, Liang L, Zhou ZC et al: MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target. Theranostics 2022, 12(15):6509-6526.

18. Guo YG, Zhu ZH, Huang ZY, Cui L, Yu W, Hong WJ, Zhou ZC, Du P, Liu CY: CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis. Nature Communications 2022, 13(1):4995.

19. Chen K, Tang Y, Wu M, Wan XC, Zhang YN, Chen XX, Yu FQ, Cui ZH, Ma JM, Zhou ZC et al: Head-to-Tail Cross-Linking to Generate Bicyclic Helical Peptides with Enhanced Helicity and Proteolytic Stability. Organic Letters 2022, 24(1):53-57.

20. An LW, Cao ZF, Nie PP, Zhang H, Tong ZZ, Chen F, Tang Y, Han Y, Wang WJ, Zhao ZT et al: Combinatorial targeting of Hippo-STRIPAK and PARP elicits synthetic lethality in gastrointestinal cancers. Journal of Clinical Investigation 2022, 132(9).

21. 张慧, 聂平平, 焦石, 周兆才: 胃肠道肿瘤发生及免疫应答的细胞信号机制. 生命的化学 2022, 42(05):882-891.

22. 曹智发, 汤扬, 聂平平, 韩毅, 周兆才, 安利伟: STRIPAK复合物与肿瘤发生. 中国细胞生物学学报 2022, 44(04):758-769.

23. Zhou ZC, Yuan ZQ, Hong WJ, Wang WQ: Editorial: A Hippo's View: From Molecular Basis to Translational Medicine. Frontiers in Cell and Developmental Biology 2021, 9:729155.

24. Zhou FQ, Gao J, Tang Y, Zou ZF, Jiao S, Zhou ZC, Xu HX, Xu ZP, Yu HJ, Xu ZA: Engineering Chameleon Prodrug Nanovesicles to Increase Antigen Presentation and Inhibit PD-L1 Expression for Circumventing Immune Resistance of Cancer. Advanced Materials 2021, 33(43):e2102668.

25. Zhang H, Lin MB, Dong C, Tang Y, An LW, Ju JY, Wen FP, Chen F, Wang M, Wang WJ et al: An MST4-pβ-Catenin

Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis. Advanced Science 2021, 8(17):e2004850.

26. Meng Y, Zhao QD, An LW, Jiao S, Li R, Sang Y, Liao JP, Nie PP, Wen FP, Ju JY et al: A TNFR2-hnRNPK Axis Promotes Primary Liver Cancer Development via Activation of YAP Signaling in Hepatic Progenitor Cells. Cancer Research 2021, 81(11):3036-3050.

27. Li Q, Zhou YX, He WD, Ren XM, Zhang MZ, Jiang Y, Zhou ZC, Luan YX: Platelet-armored nanoplatform to harmonize janus-faced IFN-γ against tumor recurrence and metastasis. Journal of Controlled Release 2021, 338:33-45.

28. Li GY, Hu XW, Nie PP, Mang DZ, Jiao S, Zhang SJ, Roy SR, Yukawa S, Asahina S, Sugasawa H et al: Lipid-Raft-Targeted Molecular Self-Assembly Inactivates YAP to Treat Ovarian Cancer. Nano Letters 2021, 21(1):747-755.

29. Huang MN, Yang L, Jiang N, Dai QH, Li RS, Zhou ZC, Zhao B, Lin XH: Emc3 maintains intestinal homeostasis by preserving secretory lineages. Mucosal Immunology 2021, 14(4):873-886.

30. He LW, Li HG, Pan CY, Hua YT, Peng JY, Zhou ZC, Zhao Y, Lin MB: Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediated MAPK signaling. Cancer Communications 2021, 41(8):726-746.

31. Chen XX, Tang Y, Wu M, Zhang YN, Chen K, Zhou ZC, Fang GM: Helix-Constrained Peptides Constructed by Head-to-Side Chain Cross-Linking Strategies. Organic Letters 2021, 23(20):7792-7796.

32. Chen BN, Chan WN, Mui CW, Liu XL, Zhang JL, Wang YF, Cheung AHK, Chan AKY, Chan RCK, Leung KT et al: STK3 promotes gastric carcinogenesis by activating Ras-MAPK mediated cell cycle progression and serves as an independent prognostic biomarker. Molecular Cancer 2021, 20(1):147.

33. An L, Yu R, Han Y, Zhou Z: Decoding the intercellular communication network during tumorigenesis. Cancer Biology and Medicine 2021, 18(-):0-0.

34. Xu JZ, Tang Y, Sheng XL, Tian YH, Deng M, Du SJ, Lv C, Li GL, Pan YW, Song YL et al: Secreted stromal protein ISLR promotes intestinal regeneration by suppressing epithelial Hippo signaling. Embo Journal 2020, 39(7):e103255.

35. Tang Y, Fang GM, Guo FH, Zhang H, Chen XX, An LW, Chen M, Zhou L, Wang WJ, Ye TT et al: Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer. Cancer Cell 2020, 38(1):115-+.

36. Tan CX, Dong ZG, Li YH, Zhao HG, Huang XY, Zhou ZC, Jiang JW, Long YZ, Jiang PK, Zhang TY et al: A high performance wearable strain sensor with advanced thermal management for motion monitoring. Nature Communications 2020, 11(1):3530.

37. An LW, Nie PP, Chen M, Tang Y, Zhang H, Guan JM, Cao ZF, Hou C, Wang WJ, Zhao Y et al: MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway. Journal of Experimental Medicine 2020, 217(6).

38. Tang Y, Chen M, Zhou L, Ma J, Li YH, Zhang H, Shi ZB, Xu Q, Zhang XM, Gao ZY et al: Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling. Cell Discovery 2019, 5:3.

39. Liu CX, Li X, Nan F, Jiang S, Gao X, Guo SK, Xue W, Cui YG, Dong KG, Ding HH et al: Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity. Cell 2019, 177(4):865-+.

40. Li YH, Guan JM, Wang WJ, Hou C, Zhou L, Ma J, Cheng YF, Jiao S, Zhou ZC: TRAF3-interacting JNK-activating modulator promotes inflammation by stimulating translocation of Toll-like receptor 4 to lipid rafts. Journal of Biological Chemistry 2019, 294(8):2744-2756.

41. Sun WW, Jiao S, Sun L, Zhou ZC, Jin X, Wang JH: SUN2 Modulates HIV-1 Infection and Latency through Association with Lamin A/C To Maintain the Repressive Chromatin. Mbio 2018, 9(3).

42. Shi Z, Zhou Z: MST kinases in innate immune signaling. Cell Stress 2018, 2(1):4-13.

43. Jiao S, Guan JM, Chen M, Wang WJ, Li CC, Wang YG, Cheng YF, Zhou ZC: Targeting IRF3 as a YAP agonist therapy against gastric cancer. Journal of Experimental Medicine 2018, 215(2):699-718.

44. Chen M, Zhang H, Shi ZB, Li YH, Zhang XM, Gao ZY, Zhou L, Ma J, Xu Q, Guan JM et al: The MST4-MOB4 complex disrupts the MST1-MOB1 complex in the Hippo-YAP pathway and plays a pro-oncogenic role in pancreatic cancer. Journal of Biological Chemistry 2018, 293(37):14455-14469.

45. Shi Z, He F, Chen M, Hua L, Wang W, Jiao S, Zhou Z: DNA-binding mechanism of the Hippo pathway transcription factor TEAD4. Oncogene 2017, 36(30):4362-4369.

46. Pan CY, Xiong Y, Lv XD, Xia YX, Zhang S, Chen H, Fan JL, Wu WQ, Liu F, Wu HL et al: UbcD1 regulates Hedgehog signaling by directly modulating Ci ubiquitination and processing. Embo Reports 2017, 18(11):1922-1934.

47. Jiao S, Li CC, Hao Q, Miao HF, Zhang L, Li L, Zhou ZC: VGLL4 targets a TCF4-TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer. Nature Communications 2017, 8:14058.

48. Fan J, Kuai B, Wu GF, Wu XD, Chi BK, Wang LT, Wang K, Shi ZB, Zhang H, Chen S et al: Exosome cofactor hMTR4 competes with export adaptor ALYREF to ensure balanced nuclear RNA pools for degradation and export. Embo Journal 2017, 36(19):2870-2886.

49. Xu K, Liu HF, Shi ZB, Song GR, Zhu XY, Jiang YZ, Zhou ZC, Liu XL: Disruption of the RAG2 zinc finger motif impairs protein stability and causes immunodeficiency. European journal of immunology 2016, 46(4):1011-1019.

50. Wang DG, Wang TT, Liu JP, Yu HJ, Jiao S, Feng B, Zhou FY, Fu YL, Yin Q, Zhang PC et al: Acid-Activatable Versatile Micelleplexes for PD-L1 Blockade Enhanced Cancer Photodynamic Immunotherapy. Nano Letters 2016, 16(9):5503-5513.

51. Wang CC, Zeng XL, Zhou ZC, Zhao J, Pei G: β-arrestin-1 contributes to brown fat function and directly interacts with PPARα and PPARγ. Scientific Reports 2016, 6:26999.

52. Shi Z, Jiao S, Zhou Z: STRIPAK complexes in cell signaling and cancer. Oncogene 2016, 35(35):4549-4557.

53. Lv XD, Han ZJ, Chen H, Yang B, Yang XF, Xia YX, Pan CY, Fu L, Zhang S, Han H et al: A positive role for polycomb in transcriptional regulation via H4K20me1. Cell research 2016, 26(5):529-542.

54. Zhang Z, Wang YY, Li CC, Shi ZB, Hao Q, Wang WJ, Song XM, Zhao Y, Jiao S, Zhou ZC: The Transitional Endoplasmic Reticulum ATPase p97 Regulates the Alternative Nuclear Factor NF-κB Signaling via Partial Degradation of the NF-κB Subunit p100. Journal of Biological Chemistry 2015, 290(32):19558-19568.

55. Shi ZB, Zhang Z, Zhang ZZ, Wang YY, Li CC, Wang X, He F, Sun LN, Jiao S, Shi WY et al: Structural Insights into Mitochondrial Antiviral Signaling Protein (MAVS)-Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Signaling. Journal of Biological Chemistry 2015, 290(44):26811-26820.

56. Shi ZB, Jiao S, Zhou ZC: Structural dissection of Hippo signaling. Acta biochimica et biophysica Sinica 2015, 47(1):29-38.

57. Jiao S, Zhang Z, Li CC, Huang M, Shi ZB, Wang YY, Song XM, Liu H, Li CY, Chen M et al: The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6. Nature immunology 2015, 16(3):246-U204.

58. Hao Q, Jiao S, Shi ZB, Li CC, Meng X, Zhang Z, Wang YY, Song XM, Wang WJ, Zhang RG et al: A non-canonical role of the p97 complex in RIG-I antiviral signaling. Embo Journal 2015, 34(23):2903-2920.

59. Han H, Pan CY, Liu CY, Lv XD, Yang XF, Xiong Y, Lu Y, Wu WQ, Han JH, Zhou ZC et al: Gut-neuron interaction via Hh signaling regulates intestinal progenitor cell differentiation in. Cell Discovery 2015, 1:15006.

60. Zhang WJ, Gao YJ, Li PX, Shi ZB, Guo T, Li F, Han XK, Feng Y, Zheng C, Wang ZY et al: VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex. Cell research 2014, 24(3):331-343.

61. Xiao Y, Nagai Y, Deng GP, Ohtani T, Zhu ZQ, Zhou ZC, Zhang HT, Ji MQ, Lough JW, Samanta A et al: Dynamic Interactions between TIP60 and p300 Regulate FOXP3 Function through a Structural Switch Defined by a Single Lysine on TIP60. Cell reports 2014, 7(5):1471-1480.

62. Mao FF, Yang XF, Fu L, Lv XD, Zhang Z, Wu WQ, Yang SQ, Zhou ZC, Zhang L, Zhao Y: The Kto-Skd Complex Can Regulate Expression by Interacting with (Ci) in the Hedgehog Signaling Pathway. Journal of Biological Chemistry 2014, 289(32):22333-22341.

63. Liu G, Shi Z, Jiao S, Zhang Z, Wang W, Chen C, Hao Q, Zhang M, Feng M, Xu L et al: Structure of MST2 SARAH domain provides insights into its interaction with RAPL. Journal of structural biology 2014, 185(3):366-374.

64. Li CC, Feng M, Shi ZB, Hao Q, Song XM, Wang WJ, Zhao Y, Jiao S, Zhou ZC: Structural and Biochemical Insights into the Activation Mechanisms of Germinal Center Kinase OSR1. Journal of Biological Chemistry 2014, 289(52):35969-35978.

65. Jiao S, Wang H, Shi Z, Dong A, Zhang W, Song X, He F, Wang Y, Zhang Z, Wang W et al: A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer. Cancer cell 2014, 25(2):166-180.

66. Hao Q, Feng M, Shi Z, Li C, Chen M, Wang W, Zhang M, Jiao S, Zhou Z: Structural insights into regulatory mechanisms of MO25-mediated kinase activation. Journal of structural biology 2014, 186(2):224-233.

67. Chen C, Shi Z, Zhang W, Chen M, He F, Zhang Z, Wang Y, Feng M, Wang W, Zhao Y et al: Striatins contain a noncanonical coiled coil that binds protein phosphatase 2A A subunit to form a 2:2 heterotetrameric core of striatin-interacting phosphatase and kinase (STRIPAK) complex. The Journal of biological chemistry 2014, 289(14):9651-9661.

68. Zhang Z, Feng J, Pan C, Lv X, Wu W, Zhou Z, Liu F, Zhang L, Zhao Y: Atrophin-Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR. The Journal of cell biology 2013, 203(4):575-583.

69. Zhang M, Dong L, Shi Z, Jiao S, Zhang Z, Zhang W, Liu G, Chen C, Feng M, Hao Q et al: Structural mechanism of CCM3 heterodimerization with GCKIII kinases. Structure (London, England : 1993) 2013, 21(4):680-688.

70. Yang X, Mao F, Lv X, Zhang Z, Fu L, Lu Y, Wu W, Zhou Z, Zhang L, Zhao Y: Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling. Journal of cell science 2013, 126(Pt 18):4230-4238.

71. Shi Z, Jiao S, Zhang Z, Ma M, Zhang Z, Chen C, Wang K, Wang H, Wang W, Zhang L et al: Structure of the MST4 in complex with MO25 provides insights into its activation mechanism. Structure (London, England : 1993) 2013, 21(3):449-461.

72. Shi D, Lv X, Zhang Z, Yang X, Zhou Z, Zhang L, Zhao Y: Smoothened oligomerization/higher order clustering in lipid rafts is essential for high Hedgehog activity transduction. The Journal of biological chemistry 2013, 288(18):12605-12614.

73. Li B, Wang C, Zhou Z, Zhao J, Pei G: beta-Arrestin-1 directly interacts with Galphas and regulates its function. FEBS letters 2013, 587(5):410-416.

74. Huang HL, Wang S, Yin MX, Dong L, Wang C, Wu W, Lu Y, Feng M, Dai C, Guo X et al: Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association. PLoS biology 2013, 11(8):e1001620.

75. Guo T, Lu Y, Li P, Yin MX, Lv D, Zhang W, Wang H, Zhou Z, Ji H, Zhao Y et al: A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity. Cell research 2013, 23(10):1201-1214.

76. Feng M, Ding Z, Xu L, Kong L, Wang W, Jiao S, Shi Z, Greene MI, Cong Y, Zhou Z: Structural and biochemical studies of RIG-I antiviral signaling. Protein & cell 2013, 4(2):142-154.

77. Zhou Z, Du X, Cai Z, Song X, Zhang H, Mizuno T, Suzuki E, Yee MR, Berezov A, Murali R et al: Structure of Sad1-UNC84 homology (SUN) domain defines features of molecular bridge in nuclear envelope. The Journal of biological chemistry 2012, 287(8):5317-5326.

78. Yin H, Shi Z, Jiao S, Chen C, Wang W, Greene MI, Zhou Z: Germinal center kinases in immune regulation. Cellular & molecular immunology 2012, 9(6):439-445.

79. Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z: Structural insights into SUN-KASH complexes across the nuclear envelope. Cell research 2012, 22(10):1440-1452.

80. Song X, Li B, Xiao Y, Chen C, Wang Q, Liu Y, Berezov A, Xu C, Gao Y, Li Z et al: Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function. Cell reports 2012, 1(6):665-675.

81. Runkle EA, Zhang H, Cai Z, Zhu Z, Karger BL, Wu SL, O'Rourke DM, Zhou Z, Wang Q, Greene MI: Reversion of the ErbB malignant phenotype and the DNA damage response. Experimental and molecular pathology 2012, 93(3):324-333.

82. Jin Y, Dong L, Lu Y, Wu W, Hao Q, Zhou Z, Jiang J, Zhao Y, Zhang L: Dimerization and cytoplasmic localization regulate Hippo kinase signaling activity in organ size control. The Journal of biological chemistry 2012, 287(8):5784-5796.

83. Deng G, Xiao Y, Zhou Z, Nagai Y, Zhang H, Li B, Greene MI: Molecular and biological role of the FOXP3 N-terminal domain in immune regulation by T regulatory/suppressor cells. Experimental and molecular pathology 2012, 93(3):334-338.

84. Song X, Zhang M, Zhou Z, Gong W: Ultra-high resolution crystal structure of a dimeric defensin SPE10. FEBS letters 2011, 585(2):300-306.

85. Xiao Y, Li B, Zhou Z, Hancock WW, Zhang H, Greene MI: Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function. Current opinion in immunology 2010, 22(5):583-591.

86. Zhou Z, Song X, Berezov A, Li B, Greene MI: Structural aspects of the FOXP3 regulatory complex as an immunopharmacological target. International immunopharmacology 2009, 9(5):518-520.

87. Zhou Z, Tone Y, Song X, Furuuchi K, Lear JD, Waldmann H, Tone M, Greene MI, Murali R: Structural basis for ligand-mediated mouse GITR activation. Proceedings of the National Academy of Sciences of the United States of America 2008, 105(2):641-645.

88. Zhou Z, Song X, Li B, Greene MI: FOXP3 and its partners: structural and biochemical insights into the regulation of FOXP3 activity. Immunologic research 2008, 42(1-3):19-28.

89. Zhou Z, Song X, Berezov A, Zhang G, Li Y, Zhang H, Murali R, Li B, Greene MI: Human glucocorticoid-induced TNF receptor ligand regulates its signaling activity through multiple oligomerization states. Proceedings of the National Academy of Sciences of the United States of America 2008, 105(14):5465-5470.

90. Cai Z, Zhang G, Zhou Z, Bembas K, Drebin JA, Greene MI, Zhang H: Differential binding patterns of monoclonal antibody 2C4 to the ErbB3-p185her2/neu and the EGFR-p185her2/neu complexes. Oncogene 2008, 27(27):3870-3874.

91. Zhou Z, Song X, Gong W: Novel conformational states of peptide deformylase from pathogenic bacterium Leptospira interrogans: implications for population shift. The Journal of biological chemistry 2005, 280(51):42391-42396.

92. Li S, Zhou Z, Chu W, Gong W, Benfatto M, Hu T, Xie Y, Xian D, Wu Z: Investigation of zinc-containing peptide deformylase from Leptospira interrogans by X-ray absorption near-edge spectroscopy. Journal of synchrotron radiation 2005, 12(Pt 1):111-114.

93. Brown JH, Zhou Z, Reshetnikova L, Robinson H, Yammani RD, Tobacman LS, Cohen C: Structure of the mid-region of tropomyosin: bending and binding sites for actin. Proceedings of the National Academy of Sciences of the United States of America 2005, 102(52):18878-18883.

94. Zhou Z, Song X, Li Y, Gong W: Unique structural characteristics of peptide deformylase from pathogenic bacterium Leptospira interrogans. Journal of molecular biology 2004, 339(1):207-215.

95. Zhou Z, Gong W: Co-crystallization of Leptospira interrogans peptide deformylase with a potent inhibitor and molecular-replacement schemes with eight subunits in an asymmetric unit. Acta crystallographica Section D, Biological crystallography 2004, 60(Pt 1):137-139.

96. Wei Z, Zhang P, Zhou Z, Cheng Z, Wan M, Gong W: Crystal structure of human eIF3k, the first structure of eIF3 subunits. The Journal of biological chemistry 2004, 279(33):34983-34990.

97. Song X, Zhou Z, Wang J, Wu F, Gong W: Purification, characterization and preliminary crystallographic studies of a novel plant defensin from Pachyrrhizus erosus seeds. Acta crystallographica Section D, Biological crystallography 2004, 60(Pt 6):1121-1124.

98. Liu L, Wang Y, Zhang P, Cheng Z, Wan M, Zhou Z, Gong W: Expression, purification and preliminary crystallographic studies of human coactosin-like protein. Acta crystallographica Section D, Biological crystallography 2004, 60(Pt 9):1651-1653.

99. Chang S, Song X, Yan M, Zhou Z, Wu F, Gong W: Purification, characterization and preliminary crystallographic studies of a cysteine protease from Pachyrrhizus erosus seeds. Acta crystallographica Section D, Biological crystallography 2004, 60(Pt 1):187-189.

100. Wu F, Yan M, Li Y, Chang S, Song X, Zhou Z, Gong W: cDNA cloning, expression, and mutagenesis of a PR-10 protein SPE-16 from the seeds of Pachyrrhizus erosus. Biochemical and biophysical research communications 2003, 312(3):761-766.

101. Zhou Z, Liu H, Li Y, Gong W: Purification, crystallization and preliminary crystallographic studies of a class II chitinase from kidney bean seeds. Protein and peptide letters 2002, 9(3):265-268.

102. Wu F, Li Y, Chang S, Zhou Z, Wang F, Song X, Lin Y, Gong W: Purification, characterization and preliminary crystallographic studies of a PR-10 protein from Pachyrrhizus erosus seeds. Acta crystallographica Section D, Biological crystallography 2002, 58(Pt 12):2165-2167.